Gynecologic Cancer InterGroup (GCIG) consensus review for high-grade undifferentiated sarcomas of the uterus.
Identifieur interne : 003877 ( Main/Exploration ); précédent : 003876; suivant : 003878Gynecologic Cancer InterGroup (GCIG) consensus review for high-grade undifferentiated sarcomas of the uterus.
Auteurs : Patricia Pautier ; Eun Ji Nam ; Diane M. Provencher ; Anne L. Hamilton ; Giorgia Mangili ; Nadeem Ahmad Siddiqui ; Anneke M. Westermann ; Nicholas Simon Reed ; Philipp Harter ; Isabelle Ray-CoquardSource :
- International journal of gynecological cancer : official journal of the International Gynecological Cancer Society [ 1525-1438 ] ; 2014.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- pathology : Sarcoma, Uterine Neoplasms.
- therapy : Sarcoma, Uterine Neoplasms.
- Combined Modality Therapy, Consensus, Female, Humans, Medical Oncology, Neoplasm Grading, Practice Guidelines as Topic, Societies, Medical.
Abstract
High-grade undifferentiated sarcomas (HGUSs) are rare uterine malignancies arising from the endometrial stroma. They are poorly differentiated sarcomas composed of cells that do not resemble proliferative-phase endometrial stroma. High-grade undifferentiated sarcomas are characterized by aggressive behavior and poor prognosis. Cyclin D1 has been reported as a diagnostic immunomarker for high-grade endometrial stromal sarcoma with an YWHAE-FAM22 rearrangement. YWHAE-FAM22 endometrial stromal sarcomas (ESS) represent a clinically aggressive subtype of ESS classified as high-grade endometrial sarcomas, and its distinction from the usual low-grade ESS with JAZF1 rearrangement and from HGUS with no identifiable molecular aberration may be important in guiding clinical management. Median age of the patients is between 55 and 60 years. The most common symptoms are vaginal bleeding, abdominal pain, and increasing abdominal girth.Disease is usually advanced with approximately 70% of the patients staged III to IV according to the International Federation of Gynecology and Obstetrics classification. Preferential metastatic locations include peritoneum, lungs, intra-abdominal lymph nodes, and bone. Median progression-free survival ranged from 7 to 10 months, and median overall survival ranged from 11 to 23 months. There is no clear prognostic factor identified for HGUS, not even stage. The standard management for HGUS consists of total hysterectomy and bilateral salpingo-oophorectomy. Systematic lymphadenectomy is not recommended. Adjuvant therapies, such as chemotherapy and radiotherapy, have to be discussed in multidisciplinary staff meetings.
DOI: 10.1097/IGC.0000000000000281
PubMed: 25341584
Affiliations:
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Provencher</name></author><author><name sortKey="Hamilton, Anne L" sort="Hamilton, Anne L" uniqKey="Hamilton A" first="Anne L" last="Hamilton">Anne L. Hamilton</name></author><author><name sortKey="Mangili, Giorgia" sort="Mangili, Giorgia" uniqKey="Mangili G" first="Giorgia" last="Mangili">Giorgia Mangili</name></author><author><name sortKey="Siddiqui, Nadeem Ahmad" sort="Siddiqui, Nadeem Ahmad" uniqKey="Siddiqui N" first="Nadeem Ahmad" last="Siddiqui">Nadeem Ahmad Siddiqui</name></author><author><name sortKey="Westermann, Anneke M" sort="Westermann, Anneke M" uniqKey="Westermann A" first="Anneke M" last="Westermann">Anneke M. Westermann</name></author><author><name sortKey="Reed, Nicholas Simon" sort="Reed, Nicholas Simon" uniqKey="Reed N" first="Nicholas Simon" last="Reed">Nicholas Simon Reed</name></author><author><name sortKey="Harter, Philipp" sort="Harter, Philipp" uniqKey="Harter P" first="Philipp" last="Harter">Philipp Harter</name></author><author><name sortKey="Ray Coquard, Isabelle" sort="Ray Coquard, Isabelle" uniqKey="Ray Coquard I" first="Isabelle" last="Ray-Coquard">Isabelle Ray-Coquard</name></author></analytic><series><title level="j">International journal of gynecological cancer : official journal of the International Gynecological Cancer Society</title><idno type="eISSN">1525-1438</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Combined Modality Therapy</term><term>Consensus</term><term>Female</term><term>Humans</term><term>Medical Oncology</term><term>Neoplasm Grading</term><term>Practice Guidelines as Topic</term><term>Sarcoma (pathology)</term><term>Sarcoma (therapy)</term><term>Societies, Medical</term><term>Uterine Neoplasms (pathology)</term><term>Uterine Neoplasms (therapy)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Association thérapeutique</term><term>Consensus</term><term>Femelle</term><term>Grading des tumeurs</term><term>Guides de bonnes pratiques cliniques comme sujet</term><term>Humains</term><term>Oncologie médicale</term><term>Sarcomes ()</term><term>Sarcomes (anatomopathologie)</term><term>Sociétés médicales</term><term>Tumeurs de l'utérus ()</term><term>Tumeurs de l'utérus (anatomopathologie)</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Sarcomes</term><term>Tumeurs de l'utérus</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Sarcoma</term><term>Uterine Neoplasms</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Sarcoma</term><term>Uterine Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Combined Modality Therapy</term><term>Consensus</term><term>Female</term><term>Humans</term><term>Medical Oncology</term><term>Neoplasm Grading</term><term>Practice Guidelines as Topic</term><term>Societies, Medical</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Association thérapeutique</term><term>Consensus</term><term>Femelle</term><term>Grading des tumeurs</term><term>Guides de bonnes pratiques cliniques comme sujet</term><term>Humains</term><term>Oncologie médicale</term><term>Sarcomes</term><term>Sociétés médicales</term><term>Tumeurs de l'utérus</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">High-grade undifferentiated sarcomas (HGUSs) are rare uterine malignancies arising from the endometrial stroma. They are poorly differentiated sarcomas composed of cells that do not resemble proliferative-phase endometrial stroma. High-grade undifferentiated sarcomas are characterized by aggressive behavior and poor prognosis. Cyclin D1 has been reported as a diagnostic immunomarker for high-grade endometrial stromal sarcoma with an YWHAE-FAM22 rearrangement. YWHAE-FAM22 endometrial stromal sarcomas (ESS) represent a clinically aggressive subtype of ESS classified as high-grade endometrial sarcomas, and its distinction from the usual low-grade ESS with JAZF1 rearrangement and from HGUS with no identifiable molecular aberration may be important in guiding clinical management. Median age of the patients is between 55 and 60 years. The most common symptoms are vaginal bleeding, abdominal pain, and increasing abdominal girth.Disease is usually advanced with approximately 70% of the patients staged III to IV according to the International Federation of Gynecology and Obstetrics classification. Preferential metastatic locations include peritoneum, lungs, intra-abdominal lymph nodes, and bone. Median progression-free survival ranged from 7 to 10 months, and median overall survival ranged from 11 to 23 months. There is no clear prognostic factor identified for HGUS, not even stage. The standard management for HGUS consists of total hysterectomy and bilateral salpingo-oophorectomy. Systematic lymphadenectomy is not recommended. Adjuvant therapies, such as chemotherapy and radiotherapy, have to be discussed in multidisciplinary staff meetings.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Hamilton, Anne L" sort="Hamilton, Anne L" uniqKey="Hamilton A" first="Anne L" last="Hamilton">Anne L. Hamilton</name><name sortKey="Harter, Philipp" sort="Harter, Philipp" uniqKey="Harter P" first="Philipp" last="Harter">Philipp Harter</name><name sortKey="Mangili, Giorgia" sort="Mangili, Giorgia" uniqKey="Mangili G" first="Giorgia" last="Mangili">Giorgia Mangili</name><name sortKey="Nam, Eun Ji" sort="Nam, Eun Ji" uniqKey="Nam E" first="Eun Ji" last="Nam">Eun Ji Nam</name><name sortKey="Pautier, Patricia" sort="Pautier, Patricia" uniqKey="Pautier P" first="Patricia" last="Pautier">Patricia Pautier</name><name sortKey="Provencher, Diane M" sort="Provencher, Diane M" uniqKey="Provencher D" first="Diane M" last="Provencher">Diane M. Provencher</name><name sortKey="Ray Coquard, Isabelle" sort="Ray Coquard, Isabelle" uniqKey="Ray Coquard I" first="Isabelle" last="Ray-Coquard">Isabelle Ray-Coquard</name><name sortKey="Reed, Nicholas Simon" sort="Reed, Nicholas Simon" uniqKey="Reed N" first="Nicholas Simon" last="Reed">Nicholas Simon Reed</name><name sortKey="Siddiqui, Nadeem Ahmad" sort="Siddiqui, Nadeem Ahmad" uniqKey="Siddiqui N" first="Nadeem Ahmad" last="Siddiqui">Nadeem Ahmad Siddiqui</name><name sortKey="Westermann, Anneke M" sort="Westermann, Anneke M" uniqKey="Westermann A" first="Anneke M" last="Westermann">Anneke M. Westermann</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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